Contributes to the organization of the actin cytoskeleton and cell shape . Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones . Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density . Plays a role in focal adhesion assembly and turnover . In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate -mediated endothelial cell barrier enhancement . Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane . Plays a role in receptor-mediated endocytosis via clathrin-coated pits . Required for stabilization of KCNH1 channels at the cell membrane . Plays a role in the invasiveness of cancer cells, and the formation of metastases .

Src substrate cortactin (Amplaxin) (Oncogene EMS1)

q14247

Human,Mouse,Rat

WB,IHC,IF,ICC,IP,FC

WB 1:5000-1:50000
IHC 1:100-1:200
IF 1:500-1:1000
ICC 1:500-1:1000
IP 1:50
FC 1:20

~62 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.