Receptor for glucocorticoids . Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements , both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors . Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling . Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone stimulation and could reveal an essential role of hepatic GR in the control of body growth . ; [Isoform Alpha]: Has transcriptional activation and repression activity . Mediates glucocorticoid-induced apoptosis . Promotes accurate chromosome segregation during mitosis . May act as a tumor suppressor . May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression . ; [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha . Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed . Loses this transcription modulator function on its own . Has no hormone-binding activity . May play a role in controlling glucose metabolism by maintaining insulin sensitivity . Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner . Directly regulates STAT1 expression in isoform Alpha-independent manner . ; [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism .; [Isoform GR-P]: Increases activity of isoform Alpha. ; [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. ; [Isoform 10]: Has transcriptional activation activity. ; [Isoform Alpha-C1]: Has transcriptional activation activity. ; [Isoform Alpha-C2]: Has transcriptional activation activity. ; [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation . Has transcriptional repression activity . Mediates glucocorticoid-induced apoptosis . ; [Isoform Alpha-D1]: Has transcriptional activation activity. ; [Isoform Alpha-D2]: Has transcriptional activation activity. ; [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation . Has transcriptional repression activity .

Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)

p04150

Human

WB,IHC

WB 1:1000
IHC 1:200-1:1000

~86 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.