Biosynthesis of L-glutamate from L-aspartate or L-cysteine . Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into HS via the action of 3-mercaptopyruvate sulfurtransferase . Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes -2-aminobutanoate, a by-product in the cysteine biosynthesis pathway .

Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)

p17174

Human,Mouse,Rat

WB,IHC,IF,ICC,FC

WB 1:1000
IHC 1:100-1:200
IF 1:200-1:500
ICC 1:200-1:500
FC 1:20-1:50

~47 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.