TB2992

货号 规格 价格(¥)
TB2992S 50μl
TB2992M 100μl

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

ABMART实验方案下载

   蛋白质免疫共沉淀

   蛋白质印迹

   免疫荧光

   免疫组化

   膜再生

   植物BPP法变性蛋白提取

   组织制备成单细胞悬液

经典一抗-MiTF antibody

Datasheet

Background

Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis . Binds to M-boxes and symmetrical DNA sequences found in the promoter of pigmentation genes, such as tyrosinase . Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation . Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity . Plays an important role in melanocyte development by regulating the expression of tyrosinase and tyrosinase-related protein 1 . Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium .

Alternative Name

Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32)

Uniprot

o75030

Reactivity

Human,Mouse,Rat

Application

WB

Application Image

Recommended Dilution

WB 1:1000

Mol Weight

~59 kD

Source

Rabbit

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage

Store at -20°C. Stable for 12 months from date of receipt.

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应聘职位:hr@ab-mart.com

订购专线:4006-123-828

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技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
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北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

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