Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response . Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 . Promotes cell migration and invasion through the extracellular matrix . Required for marginal zone B-cell development and thymus-independent type 2 immune responses . Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL . Plays a role in CXCL13-induced chemotaxis of B-cells . Plays a role in the migration of olfactory sensory neurons into the forebrain and the innervation of the olfactory bulb by the OSN axons during development . Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons . ; [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 . Required for tissue-specific adhesion of T lymphocytes to peripheral tissues . Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 . May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells . ; [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway.

SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)

q8n5h7

Human,Mouse,Rat

WB

WB 1:1000

~95 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.