Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway . Plays an important role in the cascades of cellular responses evoked by changes in the environment . Mediates signal transduction of TRAF6, various cytokines including interleukin-1 , transforming growth factor-beta , TGFB-related factors like BMP2 and BMP4, toll-like receptors , tumor necrosis factor receptor CD40 and B-cell receptor . Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 . These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases ; both p38 MAPK and JNK pathways control the transcription factors activator protein-1 . Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase core complex . Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation . In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B . Promotes TRIM5 capsid-specific restriction activity . Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis . Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles .

Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)

o43318

Human,Mouse,Rat

WB,IP

WB 1:1000-1:5000
IP 1:10-1:100

~68 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.