Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site which is distinct from the classical ligand-binding site and this induces integrin conformational changes and enhanced ligand binding to site 1 . ITGA5:ITGB1 acts as a receptor for fibrillin-1 and mediates R-G-D-dependent cell adhesion to FBN1 . ITGA5:ITGB1 acts as a receptor for fibronectin and mediates R-G-D-dependent cell adhesion to FN1 . ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling . ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling . ; Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. ; Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. ; In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]

p08648

Human,Mouse,Rat

WB,IHC,IF,ICC,IP,FC

WB 1:1000-1:5000
IHC 1:100-1:200
IF 1:50
ICC 1:50
IP 1:10-1:100
FC 1:20

~115 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.