May act as a scaffolding protein within caveolar membranes . Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins to the caveolae . Interacts directly with G-protein alpha subunits and can functionally regulate their activity . Involved in the costimulatory signal essential for T-cell receptor -mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner . Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway . Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation . Binds 20-hydroxycholesterol -OHC) .

Caveolin-1

q03135

Human,Mouse,Rat

WB,IHC,IF,ICC,FC

WB 1:1000-1:5000
IHC 1:200-1:2000
IF 1:50
ICC 1:50
FC 1:20

~21 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.