Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' . Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity . Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway . Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation . Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer cells . Binds to the USP28 promoter in colorectal cancer cells . ; Upon Epstein-Barr virus infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression.

Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)

p05412

Human,Mouse,Rat

WB,IHC,IF,ICC

WB 1:1000-1:5000
IHC 1:100-1:200
IF 1:100-1:200
ICC 1:100-1:200

~36 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.