Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains . Inhibits the degradation of target proteins by the proteasome . Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains . Plays a role in the regulation of pathways leading to NF-kappa-B activation . Plays a role in the regulation of DNA repair after double-stranded DNA breaks . Acts as a chromatin regulator via its association with the Polycomb group multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex . Promotes cell proliferation by deubiquitinating phosphorylated E2F1 .

Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11)

p51784

Human,Mouse,Rat

WB,IP,FC

WB 1:1000-1:5000
IP 1:10-1:100
FC 1:200-1:1000

~110 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.