Mediates the nuclear export of proteins , such as EIF5A, SMAD3 and isoform M2 of PKM . In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex is mediated through binding to nucleoporins . Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the cargo from the export receptor . XPO4 then return to the nuclear compartment and mediate another round of transport . The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus . Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4 . Specifically mediates nuclear export of isoform M2 of PKM following PKM2 deacetylation by SIRT6 . Also mediates the nuclear import of SOX transcription factors SRY and SOX2 .

Exportin-4 (Exp4)

q9c0e2

Human,Mouse,Rat

WB

WB 1:1000-1:5000

~131 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.