[Isoform 1]: Essential for normal retinal maturation and development . Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors . In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors . May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes . ; [Isoform 1]: Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. ; [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells . Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane . Acts as a coreceptor for vascular endothelial growth factor receptor 2 in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling . Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells . Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells . ; [Isoform 2]: Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 . Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca in the erythrocyte . This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion . ; [Isoform 2]: Can facilitate human SARS coronavirus infection via its interaction with virus-associated PPIA/CYPA. ; [Isoform 2]: Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. ; [Isoform 2]: First described as a receptor for severe acute respiratory syndrome coronavirus 2 , it is not required for SARS-CoV-2 infection. ; [Isoform 2]: Acts as a receptor for measles virus. ; [Isoform 2]: Promotes entry of pentamer-expressing human cytomegalovirus into epithelial and endothelial cells.

Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)

p35613

Human,Mouse,Rat

WB,IHC,IF,ICC

WB 1:1000-1:5000
IHC 1:200-1:500
IF 1:50-1:100
ICC 1:50-1:100

~43 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.