Multifunctional ATP-dependent helicase that unwinds G-quadruplex structures . Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses . G4 structures correspond to helical structures containing guanine tetrads . Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids . Plays a role in genomic integrity . Converts the G4-RNA structure present in telomerase RNA template component into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription . Plays a role in transcriptional regulation. Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression . Plays a role in post-transcriptional regulation . Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet -induced DNA damage . Binds to the precursor-microRNA-134 terminal loop and regulates its transport into the synapto-dendritic compartment . Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size . Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability . Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression . Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively . Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation . Involved in cytoplasmic urokinase-type plasminogen activator mRNA decay . Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 . Required for the early embryonic development and hematopoiesis . Involved in the regulation of cardioblast differentiation and proliferation during heart development . Involved in spermatogonia differentiation . May play a role in ossification .

ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE)

q8vhk9

Mouse

WB,IP

WB 1:1000
IP 1:20-1:50

~114 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.