Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 and TLR5 to mediate NF-kappa-B and interferon-regulatory factor activation, and to induce apoptosis . Ligand binding to these receptors results in TRIF recruitment through its TIR domain . Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively . Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens . Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines .

TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)

q8iuc6

Human,Mouse,Rat

WB,IP

WB 1:1000
IP 1:20-1:50

~77 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.