Receptor for retinoic acid that acts as a transcription factor . Forms homo- or heterodimers with retinoic acid receptors and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes . The RAR/RXR heterodimers bind to the retinoic acid response elements composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription . The high affinity ligand for retinoid X receptors is 9-cis retinoic acid . In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression . On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation . Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA . The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context . The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes . Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells . Acts as an enhancer of RARA binding to RARE DNA element . May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 . Promotes myelin debris phagocytosis and remyelination by macrophages . Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes . Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence .

Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)

p19793

Human, Mouse, Rat

WB,IF,ICC,IP

WB 1:1000-1:2000
IF 1:20-1:100
ICC 1:20-1:100
IP 1:20-1:50

~51 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.