Adhesive protein that mediates cell-to-cell interactions . Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins . Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation . Plays a role in modulating pulmonary endothelin EDN1 signaling . Modulates nitrous oxide signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure . Plays an important role in memory formation and synaptic plasticity in the hippocampus . Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells . Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation . Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering . Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging . In response to THBS1, negatively modulates wound healing . Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 . May play a role in membrane transport and/or integrin dependent signal transduction . May prevent premature elimination of red blood cells .

Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47)

q08722

Human

IF,ICC,FC

IF 1:100
ICC 1:100
FC 1:200-1:500

~36 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.