Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis . Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells . Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4 and CD8 T-cell subsets . Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways . In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells . ; [Isoform 3]: Enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells .

T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28)

p10747

Human,Mouse,Rat

WB,IHC,IF,ICC,IP

WB 1:1000
IHC 1:200-1:2000
IF 1:50
ICC 1:50
IP 1:20-1:50

~26 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.