Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces . Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine . MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange . Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells . Binds both Cu and its reduced form, Cu, at two juxtaposed binding sites: Cu, once reduced to Cu by vitamin C or other dietary antioxidants, transits to the other binding site . MUC2-bound Cu is protected from oxidation in aerobic environments, and can be released for nutritional delivery to cells . Mucin gels store antimicrobial molecules that participate in innate immunity . Mucin glycoproteins also house and feed the microbiome, lubricate tissue surfaces, and may facilitate the removal of contaminants and waste products from the body . Goblet cells synthesize two forms of MUC2 mucin that differ in branched chain O-glycosylation and the site of production in the colon: a 'thick' mucus that wraps the microbiota to form fecal pellets is produced in the proximal, ascending colon . 'Thick' mucus transits along the descending colon and is lubricated by a 'thin' MUC2 mucus produced in the distal colon which adheres to the 'thick' mucus .

Mucin-2 (MUC-2) (Intestinal mucin-2)

q02817

Human

WB,IHC

WB 1:1000-1:5000
IHC 1:100-1:200

~551 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.