Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity . As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF chromatin remodeling complex to establish accessible chromatin . Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway . Exhibits transactivation activity in vitro . Involved in the display of nurturing behavior towards newborns . May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy . Implicated in behavioral responses related to morphine reward and spatial memory . ; [Isoform 11]: Exhibits lower transactivation activity than isoform 1 in vitro . The heterodimer with JUN does not display any transcriptional activity, and may thereby act as an transcriptional inhibitor . May be involved in the regulation of neurogenesis in the hippocampus . May play a role in synaptic modifications in nucleus accumbens medium spiny neurons and thereby play a role in adaptive and pathological reward-dependent learning, including maladaptive responses involved in drug addiction . Seems to be more stably expressed with a half-life of ~9.5 hours in cell culture as compared to 1.5 hours half-life of isoform 1 .

Protein FosB (FosB proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 3) (Transcription factor AP-1 subunit FosB)

p53539

Human

WB,IHC,IF,ICC,IP,FC

WB 1:1000
IHC 1:200-1:500
IF 1:200-1:500
ICC 1:200-1:500
IP 1:20-1:50
FC 1:200-1:500

~36 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.