Plays a role in embryonic morphogenesis; it is involved in the regulation of endochondral skeleton formation, and the development of retinal pigment epithelium , photoreceptors and periocular tissues . ; [Indian hedgehog protein]: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity . Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product . Both activities occur in the endoplasmic reticulum . Plays a role in hedgehog paracrine signaling . Associated with the very-low-density lipoprotein particles to function as a circulating morphogen for endothelial cell integrity maintenance . ; [Indian hedgehog protein N-product]: The dually lipidated indian hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. Binds to the patched receptor, which functions in association with smoothened , to activate the transcription of target genes . Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton . Positively regulates PTHLH expression during endochondral bone formation preventing chondrocyte hypertrophy. In contrast, participates in normal chondrocyte proliferation in a PTHLH-independent pathway .

Indian hedgehog protein (IHH) (EC 3.1.-.-) (HHG-2) [Cleaved into: Indian hedgehog protein N-product]

q14623

Human,Mouse,Rat

WB,IHC

WB 1:1000-1:5000
IHC 1:200-1:1000

~46 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.