Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets . Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade . Also possesses acylglycerol transacylase and phospholipase A2 activities . Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides . Regulates adiposome size and may be involved in the degradation of adiposomes . Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids in adipocytes . Acts antagonistically with LDAH in regulation of cellular lipid stores . Inhibits LDAH-stimulated lipid droplet fusion . May play an important role in energy homeostasis . May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion .

Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) (Pigment epithelium-derived factor receptor) (PEDF-R) (TTS2.2) (Transport-secretion protein 2) (TTS2)

q96ad5

Human,Mouse,Rat

WB,IHC,IF,ICC,IP

WB 1:1000
IHC 1:500-1:2000
IF 1:200-1:500
ICC 1:200-1:500
IP 1:20-1:50

~56 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.