The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine and may act as its coreceptor in CX3CR1-dependent fractalkine signaling . ITGAV:ITGB3 binds to NRG1 and this binding is essential for NRG1-ERBB signaling . ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling . ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling . ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling . ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling . ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling . ITGAV:ITGB3 binds to PLA2G2A via a site which is distinct from the classical ligand-binding site and this induces integrin conformational changes and enhanced ligand binding to site 1 . ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 and mediate R-G-D-dependent cell adhesion to FBN1 . Integrin alpha-V/beta-6 or alpha-V/beta-8 mediates R-G-D-dependent release of transforming growth factor beta-1 from regulatory Latency-associated peptide , thereby playing a key role in TGF-beta-1 activation . ITGAV:ITGB3 acts as a receptor for CD40LG . ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP . ; Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. ; Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. ; Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. ; Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. ; Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. ; Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. ; In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]

p06756

Human,Mouse,Rat

WB,IHC

WB 1:1000
IHC 1:200-1:500

~117 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.