Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand . Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell synapses through the NRX1B-CBLN1-GRID2 triad complex . In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine . However, recent research disputes this ligand-gated cation channel activity . Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells .

Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit)

o43424

Human,Mouse,Rat

WB

WB 1:1000-1:5000

~114 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.