Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains , which act as platforms for receptor clustering and signaling . Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking . Plays a role in the activation of monocytes and B-cells . Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling . Also promotes, in B-cells, the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates . Plays an essential role in B- and T-cells homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression . Also mediates metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF-alpha and LPS signaling independent of the immune compartment .

Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)

p19397

Human

IHC

IHC 1:200-1:500

~25 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.