Plays a role in vesicle-mediated secretory processes . Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets . Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation . Plays a role in insulin secretion in response to glucose stimuli . Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain . In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone and follicle-stimulating hormone . Required to maintain normal levels of renin expression and renin release . Seems to lack intrinsic enzyme activity . May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization . ; [ICA512-transmembrane fragment]: ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules ; binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2. ; [ICA512-cleaved cytosolic fragment]: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 . Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 . ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis .

Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]

q16849

Human,Mouse,Rat

WB,IHC,IP

WB 1:1000
IHC 1:200-1:500
IP 1:20-1:50

~106 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.