Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity . Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response . Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells . Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells . Has no effect on unstimulated T cells . Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton . Has high affinity for Ca and can bind up to eight Ca ions . Displays Ca-dependent binding to phospholipid membranes . Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca-dependent interaction between phagosomes and the actin cytoskeleton . ; [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades . Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors . Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration . Promotes resolution of inflammation and wound healing . Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 .

Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]

p04083

Human,Mouse,Rat

WB

WB 1:1000-1:5000

~39 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.