Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins . Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling . During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine to ATG8 proteins, to produce a membrane-bound activated form of ATG8 . Thereby, controls the elongation of the nascent autophagosomal membrane . As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress . Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine to ATG8 . Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A virus . Regulates mitochondrial antiviral signaling -dependent type I interferon production . Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response . Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 . Plays a role in regulating morphology and function of Paneth cell .

Autophagy-related protein 16-1 (APG16-like 1)

q8c0j2

Mouse

WB

WB 1:1000

~69 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.