Transcription factor that binds DNA in a sequence-specific manner . Participates in the Wnt signaling pathway . Activates transcription of target genes in the presence of CTNNB1 and EP300 . PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 . TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 . Regulates T-cell receptor alpha enhancer function . Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression . Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling . May play a role in hair cell differentiation and follicle morphogenesis . ; [Isoform 1]: Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. ; [Isoform 3]: Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling. ; [Isoform 5]: Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells.

Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha)

q9uju2

Human

WB,IHC,IF,ICC,FC

WB 1:1000-1:5000
IHC 1:50
IF 1:50-1:200
ICC 1:50-1:200
FC 1:20-1:50

~45 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.