Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase . Regulates cell migration . In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections . Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation . Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling . Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups . Upon activation by PLEKHG4B, involved in actin cytoskeletal remodeling during epithelial cell-cell junction formation .

Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)

p60953

Human,Mouse,Rat

WB,IHC,IF,ICC,IP,FC

WB 1:2000-1:20000
IHC 1:100-1:200
IF 1:200-1:500
ICC 1:200-1:500
IP 1:20-1:50
FC 1:100-1:200

~22 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.