Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. ; A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.; Acts as a receptor for Adenovirus subgroup B2 and Ad3. ; Acts as a receptor for cultured Measles virus. ; Acts as a receptor for Herpesvirus 6/HHV-6. ; May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes .

Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)

p15529

Human

WB,IHC

WB 1:1000-1:5000
IHC 1:200-1:1000

~44 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.