Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain . Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen . This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets . ITGAV:ITGB3 binds to fractalkine and acts as its coreceptor in CX3CR1-dependent fractalkine signaling . ITGAV:ITGB3 binds to NRG1 and this binding is essential for NRG1-ERBB signaling . ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling . ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling . ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling . ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling . ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling . ITGAV:ITGB3 binds to PLA2G2A via a site which is distinct from the classical ligand-binding site and this induces integrin conformational changes and enhanced ligand binding to site 1 . ITGAV:ITGB3 acts as a receptor for fibrillin-1 and mediates R-G-D-dependent cell adhesion to FBN1 . In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition . ITGAV:ITGB3 act as a receptor for CD40LG . ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP . ; Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. ; Integrin ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9. ; Acts as a receptor for Hantaan virus. ; Integrin ITGAV:ITGB3 acts as a receptor for Cytomegalovirus/HHV-5. ; Integrin ITGA5:ITGB3 acts as a receptor for Human metapneumovirus. ; Integrin ITGAV:ITGB3 acts aP05556s a receptor for Human parechovirus 1. ; Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. ; In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)

p05106

Human,Mouse

WB,IHC

WB 1:1000
IHC 1:200-1:1000

~88 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.