Mediates export of organic anions and drugs from the cytoplasm . Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics . Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export . Hydrolyzes ATP with low efficiency . Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation . Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells . Mediates ATP-dependent, GSH-independent cyclic GMP-AMP export . Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway . Exports S-geranylgeranyl-glutathione in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 with GGT5 establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma . Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells .

Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter)

p33527

Human

WB,IHC,IF,ICC

WB 1:1000
IHC 1:500-1:2000
IF 1:100
ICC 1:100

~172 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.