Transcription factor implicated in the cell fate determination in various organs . Binds to the E-box consensus sequence 5'-CANNTG-3' . Plays a role in early and late pancreas development and differentiation . Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates . May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase . Required for the formation of pancreatic acinar and ductal cells . Plays an important role in cerebellar development . Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates .

Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA-binding subunit of transcription factor PTF1) (PTF1-p48)

q9qx98

Human,Mouse,Rat

WB,IP

WB 1:1000
IP 1:50

~36 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.