Cadherins are calcium-dependent cell adhesion proteins . They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types . This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions . It associates with alpha-catenin forming a link to the cytoskeleton . Plays a role in coupling actin fibers to cell junctions in endothelial cells, via acting as a cell junctional complex anchor for AMOTL2 and MAGI1 . Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen . These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B . Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction . Associates with CTNND1/p120-catenin to control CADH5 endocytosis .

Cadherin-5 (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)

p55284

Mouse

WB,IF,ICC,IP

WB 1:1000
IF 1:500-1:1000
ICC 1:500-1:1000
IP 1:50-1:100

~88 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.