Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' or 'Lys-16' , depending on the context . Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' , an epigenetic mark that prevents chromatin compaction . H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism . The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac . The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome . X up-regulation is required to compensate for autosomal biallelic expression . The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA . As part of the NSL histone acetyltransferase complex, catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' at transcription start sites and promotes transcription initiation . The NSL complex also acts as a regulator of gene expression in mitochondria: KAT8 associates with mitochondrial DNA and controls expression of respiratory genes in an acetyltransferase-dependent mechanism . Also functions as an acetyltransferase for non-histone targets, such as ALKBH5, COX17, IRF3, KDM1A/LSD1, LMNA, PAX7 or TP53/p53 . Acts as an inhibitor of antiviral immunity by acetylating IRF3, preventing IRF3 recruitment to promoters . Acts as a regulator of asymmetric division in muscle stem cells by mediating acetylation of PAX7 . As part of the NSL complex, acetylates TP53/p53 at 'Lys-120' . Acts as a regulator of epithelial-to-mesenchymal transition as part of the NSL complex by mediating acetylation of KDM1A/LSD1 . The NSL complex is required for nuclear architecture maintenance by mediating acetylation of LMNA . Promotes mitochondrial integrity by catalyzing acetylation of COX17 . In addition to protein acetyltransferase activity, able to mediate protein propionylation .

Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (hMOF) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-)

q9h7z6

Human,Mouse,Rat

WB,IHC,IF,ICC,IP,FC

WB 1:1000
IHC 1:200-1:500
IF 1:500-1:2000
ICC 1:500-1:2000
IP 1:100-1:200
FC 1:100-1:200

~53 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.