DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development . Acts either as a transcriptional activator or repressor . Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes . Upon DNA-binding, promotes DNA bending . Acts as a transcriptional coactivator . Stimulates Indian hedgehog -induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification . Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells . Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye . Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity . Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals . Involved in epithelial-mesenchymal transition induction by increasing cell proliferation, migration and invasion . Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression . Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation . Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells . Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression . May function as a tumor suppressor .

Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3)

q12948

Human, Mouse

WB,IHC,IF,ICC,IP,FC

WB 1:1000
IHC 1:100
IF 1:100
ICC 1:100
IP 1:20
FC 1:20

~57 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.