Plasma membrane-anchored serine protease that cleaves at arginine residues . Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate . Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells . In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia . ; Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry . The cleavage of SARS-COV2 spike glycoprotein occurs between the S2 and S2' site . Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process . Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E and human coronavirus EMC and the fusion glycoproteins F0 of Sendai virus , human metapneumovirus , human parainfluenza 1, 2, 3, 4a and 4b viruses . Essential for spread and pathogenesis of influenza A virus ; involved in proteolytic cleavage and activation of hemagglutinin protein which is essential for viral infectivity. ; Receptor for human coronavirus HKU1-CoV, acts synergistically with disialoside glycans to facilitate the entry of the virus. After binding to cell-surface disialoside glycans, the viral S protein interacts with the inactive form of TMPRSS2 and inhibits its protease activity.

Transmembrane protease serine 2 (EC 3.4.21.122) (Serine protease 10) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain]

o15393

Human

WB,IHC

WB 1:1000-1:5000
IHC 1:500-1:2000

~54 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.