Regulator of protein phosphatase 1 that acts as a positive regulator of pulmonary endothelial cell barrier function . Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation . Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity . Protects the endothelial barrier from lipopolysaccharide -induced vascular leakage . Involved in the regulation of endothelial cell filopodia extension . May be a downstream target for TGF-beta1 signaling cascade in endothelial cells . Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation . Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 . Involved in the dephosphorylation of EEF1A1 .

Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP)

q96t49

Human

WB,IP

WB 1:1000-1:5000
IP 1:20-1:50

~64 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.