Endoplasmic reticulum -bound sequence-specific transcription factor that directly binds DNA and activates transcription . Plays a role in the unfolded protein response , promoting cell survival versus ER stress-induced apoptotic cell death . Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration . Associates with chromatin to the HERPUD1 promoter . Also induces transcriptional activation of chemokine receptors . ; Plays a role in human immunodeficiency virus type 1 virus protein expression. ; [Isoform 1]: May play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus core protein. ; [Isoform 1]: Plays a role in herpes simplex virus-1 latent infection and reactivation from latency. Represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestering host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. ; [Isoform 2]: Functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases . Also decreases the acetylation level of histone H4. Does not promote the chemotactic activity of leukocyte cells. ; [Processed cyclic AMP-responsive element-binding protein 3]: This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response target genes during endoplasmic reticulum stress response. Binds the cAMP response element and C/EBP sequences present in many promoters to activate transcription of the genes. Binds to the unfolded protein response element consensus sequences sites. Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II . ; [Processed cyclic AMP-responsive element-binding protein 3]: Activates transcription of genes required for reactivation of the latent HSV-1 virus. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16. Binds DNA to the cAMP response element and C/EBP sequences present in many viral promoters. ; [Processed cyclic AMP-responsive element-binding protein 3]: It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator HCV core protein.

Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)]

o43889

Human

WB,IF,ICC,FC

WB 1:1000-1:5000
IF 1:100
ICC 1:100
FC 1:100

~42 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.