G-protein coupled receptor for 5-hydroxytryptamine . Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane and lysergic acid diethylamide . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins and modulates the activity of downstream effectors . HTR2C is coupled to G/G G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol and inositol 1,4,5-trisphosphate second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca ions from intracellular stores, respectively . Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways . Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelanocortin neurons and the release of CRH that then regulates the release of corticosterone . Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress . Plays a role in insulin sensitivity and glucose homeostasis .

5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C)

p28335

Human

WB

WB 1:1000-1:5000

~52 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.