Deacetylates a wide range of non-histone substrates . Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin . Required for cilia disassembly via deacetylation of alpha-tubulin . Alpha-tubulin deacetylation results in destabilization of dynamic microtubules . Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy . Deacetylates SQSTM1 . Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity . Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI . Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities . Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex to the MutS alpha complex , leading to tolerance of DNA damage . Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition . Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis . Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons . Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region . In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage . Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression . In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome . Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy . Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer . ; Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication.

Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)

q9ubn7

Human

WB

WB 1:1000-1:5000

~132 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.