[Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin , PRL, ACTH, luteinizing hormone and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. ; [Neuronostatin]: May enhance low-glucose-induced glucagon release by pancreatic alpha cells . This effect may be mediated by binding to GPR107 and PKA activation . May regulate cardiac contractile function . May compromise cardiomyocyte viability . In the central nervous system, may impair memory retention and may affect hippocampal excitability . May also have anxiolytic and anorexigenic effects . May play a role in arterial pressure regulation . May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH .

Somatostatin (Growth hormone release-inhibiting factor) [Cleaved into: Somatostatin-28; Somatostatin-14 (SST-14); Neuronostatin (NST)]

p61278

Human

IHC

IHC 1:100-1:200

~13 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.