ATP-dependent transporter of the ATP-binding cassette family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP and cyclic GMP , bile acids, steroid conjugates, urate, and prostaglandins . Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 and leukotriene B4 too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 . Mediates the cotransport of bile acids with reduced glutathione . Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules . Confers resistance to anticancer agents such as methotrexate .

ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4)

o15439

Human

WB,IHC,IF,ICC,IP

WB 1:1000
IHC 1:100
IF 1:50
ICC 1:50
IP 1:20-1:50

~150 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.