Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system . ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation . ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons . Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation and depression and for the formation of long-term memory . Regulates synaptic plasticity by promoting endocytosis of AMPA receptors in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis . Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses . Accumulates at weaker synapses, probably to prevent their undesired enhancement . This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material . Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory . Involved in postsynaptic trafficking and processing of amyloid-beta A4 via interaction with PSEN1 . In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation .

Activity-regulated cytoskeleton-associated protein (mArc) (Activity-regulated gene 3.1 protein) (ARC/ARG3.1) (Arg3.1)

q9wv31

Human,Mouse,Rat

WB,IHC,IP

WB 1:1000
IHC 1:100
IP 1:20-1:50

~46 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.