Cell surface proteoglycan . Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins . Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation . Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands . Positively regulates the non-canonical Wnt signaling pathway . Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression . Inhibits the dipeptidyl peptidase activity of DPP4 . Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 . Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis . Required for coronary vascular development . Plays a role in regulating cell movements during gastrulation .

Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit]

p51654

Human

WB,IHC,IF,ICC,IP,FC

WB 1:1000
IHC 1:200-1:500
IF 1:200-1:500
ICC 1:200-1:500
IP 1:20-1:50
FC 1:200-1:500

~66 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.