Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes . Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex . The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer . This receptor also binds IGF2 . Acts as a positive regulator of T-cell coactivation by binding DPP4 .

Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)

p11717

Human,Mouse,Rat

WB,IHC,IF,ICC,FC

WB 1:5000-1:50000
IHC 1:200-1:500
IF 1:200-1:1000
ICC 1:200-1:1000
FC 1:100-1:500

~275 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.