Ubiquitin-like protein modifier which can be covalently attached to target proteins and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner . Conjugation to the target protein is activated by UBA6 via adenylation of its C-terminal glycine . Promotes the expression of the proteasome subunit beta type-9 . Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha . Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells . May be involved in dendritic cell maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses . Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle . May be involved in the formation of aggresomes when proteasome is saturated or impaired . Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus -associated nephropathy .

Ubiquitin D (Diubiquitin) (Ubiquitin-like protein FAT10)

o15205

Human,Mouse

WB,IHC

WB 1:1000-1:5000
IHC 1:50-1:100

~19 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.