Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively . Can reduce HO and short chain organic, fatty acid, and phospholipid hydroperoxides . Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids or hydrolyze the sn-2 ester bond of phospholipids . These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH . Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis . Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine into phosphatidylcholine . Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate .

Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12)

p30041

Human,Mouse,Rat

WB,IHC

WB 1:1000-1:5000
IHC 1:200-1:500

~26 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.