Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors . In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation . GDNF ligands first bind their corresponding GDNFR coreceptors , triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways . Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone production, but triggers apoptosis in absence of GDNF . Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue . Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses . Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin -dependent manner . Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage . Triggers the differentiation of rapidly adapting mechanoreceptors . Involved in the development of the neural crest . Regulates nociceptor survival and size . Phosphorylates PTK2/FAK1 . ; [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL.

Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]

p07949, p35546, g3v9h8

Human,Mouse,Rat

WB,IHC,IF,ICC,IP

WB 1:1000-1:5000
IHC 1:50
IF 1:50-1:100
ICC 1:50-1:100
IP 1:10-1:100

~125 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.