13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Pore-forming subunit of two major inward rectifying Ca channels at the plasma membrane: Ca release-activated Ca channels and arachidonate-regulated Ca-selective channels . Assembles with ORAI2 and ORAI3 to form hexameric CRAC channels that mediate Ca influx upon depletion of endoplasmic reticulum Ca store and channel activation by Ca sensor STIM1, a process known as store-operated Ca entry . Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca plateaus involved in sustained Ca entry and is dispensable for cytosolic Ca oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca signaling microdomains where Ca influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. Activates NFATC2/NFAT1 and NFATC3/NFAT4-mediated transcriptional responses. CRAC channels are the main pathway for Ca influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription . Assembles with ORAI3 to form channels that mediate store-independent Ca influx in response to inflammatory metabolites arachidonate or its derivative leukotriene C4, termed ARC and LRC channels respectively . Plays a prominent role in Ca influx at the basolateral membrane of mammary epithelial cells independently of the Ca content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca for milk secretion . ; [Isoform alpha]: Pore-forming subunit of both CRAC and ARC channels. Couples Ca influx to NFAT-mediated transcriptional responses. ; [Isoform beta]: Pore-forming subunit of CRAC channels exclusively.
Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A)
q96d31
Human
WB
WB 1:1000-1:5000
~33 kD
Rabbit
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Store at -20°C. Stable for 12 months from date of receipt.
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邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
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